Liver Transplantation also known as orthotopic liver transplantation is a major surgical procedure which has given a new lease of life to thousands of patients suffering from serious liver disease. Research into the possibility of liver transplantation (LT) started before the 1960s with the pivotal baseline work of Thomas Starzl in Chicago and Boston, where the initial LT techniques were researched in dogs.
Starzl attempted the first human LT in 1963 in Denver, but a successful LT was not achieved until 1967.The first human liver transplant was performed in 1967 at the University of Colorado. While initial attempts were unsuccessful, persistent efforts by him and a handful of surgeons around the world have standardized the operation. Now most big centres across the world have a success rate of over 90% for this operation.